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If GLP-1based therapy causes low chronic pancreatitis, why was this not established in toxicology studies

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GLP-1 receptor agonists have redefined the treatment standards for type 2 diabetes by providing glycemic control with added benefits of weight loss and cardiovascular protection ( [7] ) ( [8] )

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GLP-1 receptor agonists stimulate insulin secretion from pancreatic beta cells in a glucose-dependent manner, suppress glucagon release, slow gastric emptying, and act on central nervous system pathways to reduce appetite and food intake

Natural Ways to Increase GLP-1 Levels While a lot of recent news has focused on GLP-1 agonists (such as Ozempic and Wegovy among others) and their potential role in weight loss, our bodies produce GLP-1 as well