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It follows a 16-week titration schedule starting at 0.25 mg for four weeks, increasing to 0.5 mg, then 1 mg, and finally up to 2 mg

"Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial." Nature Medicine

Because semaglutide can increase the chance of dehydration, this effect on urine is very common

It is given by capsule an hour before one or two meals a day

So its a mix of metabolic stress and then this relative caloric protein deficiency that happens. Rossi said the problem is becoming more common as the medications are increasingly used by people seeking cosmetic weight loss and who may not be getting adequate nutrition

John Wiley & Sons Ltd