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The peptide is produced using solid-phase peptide synthesis and purified via preparative HPLC to achieve high analytical purity
Compared with liraglutide alone, the combined treatment decreased time to complete a stair climb test by 1.2 s [95% confidence interval 0.61.9] (corresponding to 8.6%) and improved peak oxygen consumption by 3.0 mL/min/kg fat-free mass [95% confidence interval 0.55.5]
A common contrast therapy protocol is 15 minutes in a sauna followed by 23 minutes in a cold plunge, repeated two to three times
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