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doi: 10.3390/microorganisms8091413 139 YaribeygiH.FarrokhiF

The dose may be increased by 500 mg per day on a weekly basis, up to a maximum of 2000 mg daily (administered as 1000 mg twice daily), or less, as limited by the highest tolerated and effective dose, especially in younger children (Table 1) [42]

It is not known if intra-islet -cells production of GLP-1 is affected by the surgical procedure or, more importantly, how this axis is impaired in the metabolic syndrome, type 2 diabetes and related pathologies

Additionally, several key clinical trial readouts delivered compelling data across multiple indications, for example (see Figure 1): Semaglutide : STEP-HFpEF (functional benefits in HFpEF), STEP-9 (pain reduction in knee osteoarthritis), STEP-10 (reversion to normoglycaemia in pre-diabetic, obese patients), ESSENCE (resolution of MASH, improvement in fibrosis) Tirzepatide : SUMMIT (risk reduction in HFpEF outcomes

Conclusions GLP-1 RAs produce modest but consistent reductions in BP, typically in the range of 2-5 mm Hg systolic, with the largest effects seen in agents associated with greater weight loss