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Over a 14-day treatment period, GLP-1MK-801 synergistically lowered body weight compared with the dose-matched monotherapies and produced a vehicle-corrected weight loss of 23.2% (Fig

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This effect is thought to be mediated by increasing natriuresis (35) and vasorelaxation in the renal vasculature (36)

Both preclinical and clinical studies support that the gastric slowing that occurs with tirzepatide is due to GLP-1R agonism and not related to GIPR agonism [15]

Provider licensing and credentials: Every provider who evaluates and prescribes GLP-1 medication should be a licensed, board-certified physician (MD or DO) or an advanced practice provider (NP or PA) with prescriptive authority