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Supplemental creatine (typically 3-5 grams daily) increases intramuscular creatine phosphate stores, which is why athletes use it to maintain strength and muscle volume during caloric restriction

Fukami A, Seino Y, Ozaki N, Yamamoto M, Sugiyama C, Sakamoto-Miura E, TatsuhitoHimeno TY, Tsunekawa S, Ali S, Drucker DJ, Murata Y, Seino Y, Oiso Y, Hayashi Y

That makes tirzepatide better suited to weight loss with lean-mass protection than to aggressive muscle-building recomposition

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