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Medical supervision is important due to the potential for severe or disrupting symptoms, such as pain, neuropathy, or migraines

Observations from the global registration Phase III trials suggest that tirzepatide (a novel dual GIP/GLP-1 receptor agonist) represent advancement over current GLP-1 analogues, providing enhanced glycaemic and weight benefits with similar gastrointestinal tolerability

Once-weekly dulaglutide versus bedtime insulin glargine, both in combination with prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): a randomised, open-label, phase 3, non-inferiority study

Many patients find that a lower maintenance dose (0.40.5 mg weekly instead of the 2.4 mg treatment dose) sustains appetite control without the intensity of active weight loss, making it an affordable bridge to lifelong weight stability

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