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Because insulin release is tied to elevated glucose, GLP-1 drugs tend to carry a lower standalone risk of hypoglycemia than older agents, though that risk can increase when combined with insulin or sulfonylureas

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doi: 10.7554/eLife.88942

Second, head-to-head comparative trials between GLP-1 RA monotherapy, dual agonists, and triple agonists in MASH populations with histological endpoints are entirely lacking: current selection among agents relies on indirect comparisons across trials with different inclusion criteria and follow-up periods

Suggested nephroprotective mechanisms of glucagon-like peptide 1 receptor agonists Indirect effects by improving conventional risk factors for diabetic kidney disease Hyperglycemia plays a critical role in the pathogenesis of DKD [57,58], and GLP-1 receptor agonists have potent glucose-lowering effects [5962]

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