half life of glp-1 agonists Structure and half-lives native human GLP-1, liraglutide and Frontiers | GLP-1 receptor agonists:

Safety and tolerability at higher doses appear acceptable based on preliminary data, but long-term experience is limited

This is somewhat unsurprising, given the fact that persistently elevated androgen levels in PWA rodents have been shown to prevent ovulatory rescue after administration of more proxy activators of the reproductive axis, such as kisspeptin 46

Another potential explanation for the differential effect could be discrepancy in the study population

N Engl J Med 2015

GROMADA J, HOLST J J, RORSMAN P.Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1 [J]

reported greater weight loss in obese mice with the GLP-1/GIP/glucagon receptor triagonist compared to GLP-1 receptor agonists, GIP/GLP-1 receptor co-agonists and GLP-1/glucagon receptor agonists including semaglutide and tirzepatide [60]