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Medically reviewed by Jessica Swirble, PharmD Last update: April 16, 2026 Est
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JAMA, 319 (15), 1580-1590
Activated TGF- binds to transforming growth factor- receptor type II (TRII) and phosphorylates TRI, which in turn phosphorylates Smad proteins
Linked to Serious Pancreatitis Risk It has also been associated with rare but severe cases of acute pancreatitis, which is a potentially life-threatening inflammation of the pancreas
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