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Later medications like semaglutide and tirzepatide are engineered versions - chemically modified human GLP-1 with structural changes that prevent degradation and extend half-life from seconds to days

[DOI] [PMC free article] [PubMed] [Google Scholar] 186.Capuccio S., Scilletta S., La Rocca F., Miano N., Di Marco M., Bosco G., Barbagallo F.G., Scicali R., Piro S., Pino A

doi: 10.3748/WJG.V30.I23.2964 60 MacDonaldPEEl-kholyWRiedelMJSalapatekAMFLightPEWheelerMB
(2011) Glucose-dependent insulinotropic polypeptide: a bifunctional glucose-dependent regulator of glucagon and insulin secretion in humans

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