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Headaches occur in approximately 1015% of patients beginning GLP-1 receptor agonist therapy, making them one of the more common early side effects reported during the first two weeks of treatment

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Thus, strategies aimed to break the perpetuating cycle of weight gain, insulin resistance and increased exogenous insulin requirements (Figure 2) are highly desirable in patients with double diabetes, where clinical features of both T1D and T2D coexist in the same subject [61]

Together, these complementary dual-target strategies provide a more resilient framework against antigen escape, strengthen antitumor potency through cooperative signaling, and broaden therapeutic applicability across tumors with heterogeneous or unstable antigen profiles