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The rollercoaster history of using physiological and pharmacological properties of incretin hormones to develop diabetes medications with a convincing benefit-risk relationship

This review provides an overview regarding the effects of GIP/GLP-1 receptor agonist on the improvement of glucose control in T2DMpatients, as well as the emerging and relevant findings derived from preclinical and clinical studies focused on the Phase 3 clinical trial program of tirzepatide

However, clinical studies have not been able to determine the exact mechanism by which GLP1RA regulates hyperandrogenism

So loss in skeletal muscle (when it occurs) is more an indirect effect

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This has sparked interest in newer metabolic therapies like GLP1 receptor agonists, especially in the context of managing PCOS-related metabolic issues