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Clinical trials demonstrate that participants using semaglutide consume roughly 20% fewer calories than baseline without deliberate caloric restriction, suggesting the appetite suppression occurs at a physiological rather than behavioral level

However, body mass index (BMI) and body weight do not differentiate between fat and lean mass or account for fat distribution

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When glycogen is burned for energy, it releases water, which leads to weight loss

Since the original use for Ozempic was for type 2 diabetes management , it is also effective in preventing large spikes in blood sugar, which further allows patients to feel less hungry as they will no longer experience the extreme swings in blood sugar