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Both neuron- and astrocyte-derived estrogens are believed to contribute significantly to neuroprotection and cognitive function through interactions with ERs expressed in multiple brain regions (McEwen and Woolley, 1994

The pivotal SURMOUNT and SURPASS trial programs primarily focused on weight loss and glycemic outcomes, with reproductive health not designated as a primary endpoint

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The feeling of tiredness is usually mild and temporary, which improves over time as treatment continues

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Regular lipid profile monitoring remains essential, with non-HDL cholesterol the preferred UK measurement for treatment response