glp-1 gip Beyond the pancreas: contrasting cardiometabolic actions of and GLP1 GLP-1 & GIP Agonists |

Public Plan Spending Context The Globe and Mail reports that public plans spent $794 million on Ozempic in 2024, and if plans cover Mounjaro, it could cost them an estimated $1.97 billion over three years, about $820 million more than the plans currently spend on comparable drugs over a similar period [Source: theglobeandmail.com/business/economy/article-canada-drug-agency-mounjaro-recommendation-type-2-diabetes/]

Erectile dysfunction drugs: examples include sildenafil (Viagra), tadalafil (Cialis) Interaction: Increased risk of side effects such as headache, flushing or low blood pressure

According to Harvard Health, rarer but more serious side effects can include inflammation of the pancreas, called pancreatitis

FDAs concerns with unapproved GLP-1 drugs used for weight loss (2025)

In adipose tissue, leptin counteracts insulins action by inhibiting insulin-induced IRS-1 activation and PI3K binding [126]

Any licensed health care providerincluding primary care physicians, nurse practitioners, physician assistants, and specialists such as endocrinologists, cardiologists, and gastroenterologistscan prescribe GLP-1 medications