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Data availability The EHR database used in this study were obtained from TriNetX ( Abbreviations GLP-1RAs: Glucagon-like peptide-1 receptor agonists T2DM: Type 2 diabetes mellitus EHRs: Electronic health records SGLT2: Sodium-glucose cotransporter-2 DPP-4: Dipeptidyl peptidase-4 HR: Hazard ratios CI: Confidence intervals References Alfaris N, Waldrop S, Johnson V, Boaventura B, Kendrick K, Stanford FC (2024) GLP-1 single, dual, and triple receptor agonists for treating type 2 diabetes and obesity: a narrative review

Another study supported that the stress of hyperglycemia induced the accumulation of advanced glycation end (AGE) products, which led to an increase in reactive oxygen species, the activation of inflammatory pathways and reduction of cardiac energy efficiency [42]
PMID: 15619630

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