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However, these results were not replicated in a larger multicenter trial conducted over 96 weeks (61)

Conversely, M2 microglia promoted nerve regeneration through two pathways: (1) microglia could secrete an insulin-like growth factor (IGF-1), which increased the proliferation of neural precursor cells (NPCs)

SGLT-2 inhibitors and thiazolidinediones may also be used concurrently, though patients should be monitored for any unexpected interactions or adverse effects

K + efflux then hyperpolarises the pericyte membrane, inhibiting Ca 2+ influx through voltage-gated Ca 2+ channels and thus relaxing pericytes

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