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Due to the potential of GLP-1R antagonists to modulate T-cell regulation and the evidence that enhancing T-cell infiltration can effectively transform cold tumors into hot tumors (2729), it is plausible that combining GLP-1R antagonists with ICIs may synergistically modulate T-cell-mediated immune sensitivity to improve tumor treatment outcomes

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Meat hydrolysate has been shown to stimulate the secretion of GLP-1 via the mitogen-activated protein kinase-dependent pathway ( 19 )