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Daniel Drucker, a professor at the University of Toronto Faculty of Medicine in Canada and a former adviser to Eli Lilly, said, "It shows the most powerful weight-loss effect among GLP-1 drugs developed so far" and evaluated it as "an effect on par with bariatric surgery (metabolic surgery for obesity)." He added, "If approved, most patients who need substantial weight reduction will choose retatrutide."

People who crashed at 2.5 mg on day one often sail through 2.0 mg after a proper microdose ramp-up

They recommend consulting with a healthcare provider for individualized guidance

The injection is often administered subcutaneously, that is, under the skin, into the abdomen, thigh, and upper arm