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Depressed patients are often characterized by elevated blood cortisol levels and changes in the circadian secretion of this hormone, an increased number of corticotropin-releasing hormone (CRH)-expressing neurons in the hypothalamic paraventricular nucleus (PVN), as well as an impairment in a negative feedback mechanism, which can be measured in the dexamethasone suppression test [70, 71]

[29] mentioned that this could be due to possible anti-inflammatory routes activated by GLP-1RAs

Overall first-time prescriptions of semaglutide are down 3.22% over the time period, while overall first-time prescriptions of tirzepatide are up 38.03%

In fact, by continuously depriving the liver of esterified fatty acids and inhibiting the hepatic glycolytic pathway, glucagon promotes the production of ketone bodies [4143] Hepatic ketogenesis is boosted as a result, and mitochondrial fatty acid oxidation is improved [14, 43]

For patients, delays translate into frustration, disengagement, and, in some cases, abandonment of therapy

Offering Regular Follow-Ups: Consistent check-ins help track progress, adjust hair care routines, and maintain open communication