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The FDA has approved Wegovy (semaglutide 2.4 mg) and Zepbound (tirzepatide) for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity, when used with a reduced-calorie diet and increased physical activity

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A landmark meta-analysis found that weight reduction of 5-10% resulted in spontaneous ovulation restoration in 55-100% of women with anovulation related to obesity

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Wang SH, Sun ZL, Guo YJ, Yuan Y, Yang BQ

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