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The concept of type 2 diabetes remission is evolving rapidly, and gaining wide public and professional interest, following demonstration that with substantial intentional weight loss almost nine in ten people with type 2 diabetes can reduce their HbA1c level below the diagnostic criterion (48 mmol/mol [6.5%]) without glucose-lowering medications, and improve all features of the metabolic syndrome

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In the 3,127-participant ATTAIN-1 Phase 3 randomized placebo-controlled trial, 36 mg achieved 12.4% mean weight loss at 72 weeks versus 0.9% with placebo, with ...

This article reviews the diagnosis and decision-making process for individualized treatment.