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Glucagon-like peptide-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR), is broadly expressed on the surfaces of various cells, including the pancreas, intestine and brain [8]

Tirzepatide Pregnancy Safety Profile: Evidence Framework and Clinical Considerations Understanding the safety profile of tirzepatide in pregnancy requires examining mechanism of action, drug metabolism, and fetal exposure risk

In contrast, Tirzepatide combines GLP-1 receptor activation with GIP receptor activation, yielding a broader metabolic effect that enhances its weight loss potential