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Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling

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[DOI] [PubMed] [Google Scholar] 13.Van de Wiele VL, Kesselheim AS, Beran D, Darrow JJ

GLP mimetics are currently widely used in the treatment of Type 2 diabetes while both physiological and pathophysiological effects on the exocrine pancreas are less clear

This can inadvertently lead to weight loss and improve overall health outcomes

One exception is the class of glucagon-like peptide-1 receptor (GLP-1R) agonists, which can be used to treat not only type 2 diabetes but obesity, hyperphagia, and hypertension 5,6,7
