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Retatrutides unique molecular structure enables potent activation of GLP-1, GIP, and glucagon receptors, leading to significant weight reduction, improved glycemic control, and favorable metabolic outcomes

10.1016/j.mce.2014.11.015 60 JinS

Patients in the placebo group were more likely to use SU and insulin

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In the STEP-4 (Effect and Safety of Semaglutide 2.4 mg Once-Weekly in Subjects With Overweight or Obesity Who Have Reached Target Dose During Run-in Period) trial, 16 participants who discontinued semaglutide after 20 weeks regained a mean 6.9% of their baseline body weight over 48 weeks

It works as an appetite suppressant by stimulating the central nervous system