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But for anyone seeking transformative, sustained weight reduction, tirzepatide represents a genuine breakthrough that produces results no previous medication could achieve

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Lancet 377:13411352 Allison DB, Gadde KM, Garvey WT, Peterson CA, Schwiers ML, Najarian T, Tam PY, Troupin B, Day WW (2012) Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP)