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Dermatologists, plastic surgeons, and everyday users are noticing a distinct look that often accompanies success on these medications, one thats gaunt, slack, prematurely aged, and, by now, recognizable enough to have earned the nickname Ozempic Face. Dendy Engelman, MD, is one of those dermatologists: The skin appears thinner, and theres an almost deflated look to the mid-face and jawline, paired with dryness and fine lines, she says

Both use a gradual escalation schedule to minimize side effects

A modest heart rate increase of up to 6.7 bpm was noted in Phase 2 data

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Her insurance company, however, thought it knew better

It is administered once weekly by subcutaneous injection, with doses escalated gradually from a low starting dose up to 12 mg weekly in Phase 2 trials