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Diabetes mellitus

18 When coupled with smaller and more infrequent meals, bile salt secretion into the intestine is decreased, reducing gallbladder motility and triggering the formation of biliary sludge, i.e., crystals or microliths composed of precipitated lipid particles

The appetite-suppressing effect is often the first sign tirzepatide is working, even if your scale hasn't budged

Temporary adjustments in bowel movements, including mild diarrhea, constipation, or transient bloating

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Ozempic is FDA approved and available now by prescription, while Retatrutide remains in Phase 3 trials with expected approval in late 2026 to early 2027