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In total, 100 participants with T2D who have been treated with liraglutide (0.91.8 mg/day in plan A) or dulaglutide (0.75 mg/week in plan B) for more than 12 weeks and have a glycated hemoglobin (HbA1c) level of 6.09.9% and a body mass index (BMI) of 22 kg/m 2 will be randomized to either continue using their existing GLP-1 receptor agonist or switch to subcutaneous semaglutide once weekly for 24 weeks

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These are tested thoroughly, ensure consistent dosing, and come with established safety profiles supported by extensive clinical trials

doi: 10.4049/jimmunol.177.1.53 119 KhiljiMSFaridiPPinheiro-MaChadoEHoefnerCDahlbyTAranhaRet al

Each intervention was simulated by varying two model parameters affecting energy intake to fit the observed mean weight loss data

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