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Additionally, in response to a meal, in patients with short bowel syndrome with a preserved colon (jejuno-colonic anastomosis), both baseline GLP-1 and GLP-2 are elevated with GLP-2 levels threefold greater than control patients (average concentration of 72 pmol/L), which persists throughout the post-prandial period (Jeppesen et al., 2000)

Breastfeeding is also not recommended while taking these medications, as the SmPCs state it is unknown whether they pass into breast milk in clinically significant amounts

[DOI] [PubMed] [Google Scholar] 286.Ekberg J.H., Hauge M., Kristensen L.V., Madsen A.N., Engelstoft M.S., Husted A.S

Most clinicians avoid this combination unless a compelling clinical reason exists, as evidence for superior outcomes compared to monotherapy remains limited

Smaller water volumes give a more concentrated solution (fewer units per dose)

This makes Rybelsus an appealing option for individuals who may have reservations or concerns about using injectable medications