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Both had a similar average weight loss at the end of the trial (14.9% for Wegovy vs 15% for Mounjaro), and both had a similar amount of participants who achieved at least a 5% decrease in body weight (86.4% for Wegovy vs 85% for Mounjaro)

Evidence most strongly supports continuous therapy as the most reliable long-term approach

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Further implicating GLP-1 in the increased insulin response, administration of the GLP-1 receptor antagonist exendin(9-39) has been found to impair insulin response to an oral glucose load in both humans and rodents (39, 7173)

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