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Semaglutide is not a replacement for FDA-approved smoking cessation therapies and should not be used as a standalone quit-smoking tool

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Most health care providers recommend staying on GLP-1 medications for at least three months, but meaningful results may take six months to two years to see

Both medications act on GLP-1 receptors, which are found throughout the body, including in the brain, stomach, intestines, pancreas, and even fat cells

Notably, we recently conducted LNP-mediated knock-in of the GFP gene at the Alb locus, with GFP expression predominantly observed in hepatocytes, further confirming that hepatocytes are primary target for LNP-mediated gene delivery and genome editing 13

In TRIUMPH-4, participants taking retatrutide achieved substantial weight loss and reported improvements in pain and physical function compared to placebo