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This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

DPP-4i HR range from 0.78 [0.601.01] to 0.93 [0.831.04]) Lets conclude once and forever that there is no increased risk of thyroid tumors at all with GLP-1 RAs