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Despite promising data on animal models, clinical studies evaluating the efficacy of metformin in MASLD have yielded mixed results

However, it is not known whether these effects can also be attributed to a direct action of GLP-1 RAs

Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycaemia in non-obese diabetic mice

The odds of them sustaining this weight loss is tremendously greater than with GLP-1s

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163,165 Metformin in Impaired Glucose Tolerance/Prediabetes The drug for the initial therapy of T2D is metformin