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Glucagon-like peptide-1 receptor (GLP-1R) is widely expressed G protein-coupled receptor, mediates the effects of Glucagon-like peptide-1 (GLP-1), a peptide derived from proglucagon and produced in intestinal L-cells, pancreatic -cells, and specific brain regions (22)

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Meanwhile, oral semaglutide has shown cardiovascular safety, with outcome data continuing to evolve