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Further, in the Framingham Heart Study, almost all people with hypertension (91%) had or developed HF, the risk of which was 2-3-fold higher in hypertensive than in normotensive individuals (Vasan et al., 2001)

Phosphorylation of both IRS1 and IRS2 activates the phosphatidylinositol 3-kinase (PI3K) [105]

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Nadeem D, Taye M, Still MD, et al

2.2.4 Endoplasmic reticulum stress Endoplasmic reticulum (ER) stress plays a central role in metabolic, vascular, and neuroinflammatory disorders

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