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Weight loss can slow down, side effects can occur, and motivation can change

19 These drugs are sometimes used off-label to treat PCOS, through promoting insulin sensitivity and improving the reproductive function

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Clinical trials have shown body weight reductions of 15 to 20% in some participants, which explains why these medications have exploded in popularity beyond diabetes treatment (Wilding et al., 2021, New England Journal of Medicine)

Per the label: one capsule daily with an 8 oz

That means that a big open question is whether the side effect profiles may differ in subgroups of people that scientists have not directly studied, which include a large swath of people now taking these drugs to lose only about 10 to 15 pounds