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35 The mechanisms underlying the effect of GLP-1 receptor agonists on OSA remain incompletely understood but are believed to be largely mediated through weight reduction.[45] OFF-LABEL AND INVESTIGATIONAL USES OF GLP-1RAS Investigational and off-label indications of GLP1-RAs are conditions that may have some evidence of benefit, but which currently lack FDA approval for a particular medication

Retatrutide targets three hormone pathways (GLP-1, GIP, and glucagon), while tirzepatide targets two (GLP-1 and GIP)

An expert panel comprising endocrinologists, nephrologists, primary care physicians, cardiologists, internists and diabetes nurse educators convened across virtual meetings to reach a consensus regarding these compelling recommendations

Patients should be aware of potential side effects like nausea or gastrointestinal discomfort, but these effects often subside over time

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GLP-1 agonists were originally developed for diabetes management and offer dual benefits for eligible patients