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Filsuvez won approval based on data from the Phase III EASE study, where the drug led to accelerated wound healing, along with a reduction in overall wound burden and less pain associated with changing wound dressings

Human evidence, although limited, is more reassuring

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Thus, while causality cannot be established, the biological plausibility is strong and warrants targeted mechanistic studies

At #ASCO26, Elizabeth Susan McDonald, MD, PhD reported GLP-1 treatment was associated with lower BC incidence in women, but clinical trials are needed to confirm a true risk reduction effect

Together, the TRIUMPH, TRANSCEND, and SYNERGY programs represent one of the most comprehensive Phase 3 development programs in obesity pharmacotherapy