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Although limited data exists on pregnancy exposures, animal studies showed fetal effects at high doses

This guidance applies to all retatrutide use, but it is especially important for alternative dosing schedules

Yet a large 2025 study reported that nearly 47% of people with type 2 diabetes stopped taking these medicines within one year

Treatment with sitagliptin (20 mg/kg) increased serum GLP-1 levels in STZ-induced diabetic monkeys and showed significantly protective effects on STZ-induced islet injury in vivo and in vitro via activation of the insulin-like growth factor receptor (IGFR)/AKT/mammalian target of rapamycin (mTOR) signaling pathways [47]

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