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-Cell GLP-1 in normal glucose regulation The accepted dogma of GLP-1 secreted from the intestine and acting on the pancreas in an endocrine manner is difficult to reconcile given the observations that GLP-1 is rapidly degraded by dipeptidylpeptidase 4 (DPP4) and very little, in fact, only approximately 10% of intestinally secreted GLP-1 reaches the circulation (39, 82, 93)

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W.et al (2024)

Furthermore, anthraquinone as the main active ingredient of rhubarb root extract, augments rat ileal contraction by triggering release of endogenous acetylcholine 6

Key pathways include cAMP/PKA/CREB, PI3K/AKT, and MAPK/ERK