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Dermal Hypersensitivity Reaction to Semaglutide: Two Case Reports. Journal of Drugs in Dermatology: JDD 22.4 (2023): 413-416

As well as stimulating insulin release, GLP-1R agonists promote satiety and reduce food intake, leading to weight loss

That reduction in dose means less receptor activation

In addition, patients will often complain of bloating, dyspepsia, abdominal discomfort, and aggravation of hemorrhoids
