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It is different from long-acting insulin, metformin, and SGLT2 inhibitors, so it should not be substituted for another diabetes medicine without clinical direction

Real world practice often finds the optimal individual dose somewhere in the middle range

Biomarker Factors That Influence Your Tapering Timeline Individual metabolic markersincluding fasting glucose, insulin resistance indices (HOMA-IR), lipid panels, and GLP-1 receptor sensitivityshape how quickly you can reduce doses

For example, patients with Prader-Will syndrome (PWS) have a smaller hypothalamic PVN volume and reduction in PVN cell number [34, 44]

Deficiency of glucosedependent insulinotropic polypeptide receptor prevents ovariectomyinduced obesity in mice

Cell Physiol