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Emerson (Lee Lab), and Sneh Harsh for reading the manuscript

Unlike single-receptor target molecules, this engineered peptide features an advanced triple-agonist mechanism

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32 Furthermore, the GLP-1RA group had significantly lowered plasma glucose levels and increased serum insulin levels during the meal test after 52 weeks, in contrast to the control group, consistent with the glucoregulatory actions of GLP-1

For instance, for a onceweekly (q1wk) dose of 2.4 mg, the model predicts a steadystate body weight reduction of 17%, which is in good agreement with clinical data for q1wk dosing

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