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Reduced sensitivity to endogenous GLP-1R signaling is reported in metabolic disease 69,70 , where impairment of the intestinotrophic actions of GLP-1R and GLP-2R could extend to obesity

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Patel KA, Kettunen J, Laakso M, Stankov A, Laver TW, et al

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We think that the differences compared with our findings exceed the mere facts of using antibodies from different commercial brands or different sample numbers and could possibly arise through methodological differences in the immunohistochemical evaluations

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25 This damage culminates in geographic atrophy or disruption of Bruchs membrane, leading to severe vision loss and, in some cases, neovascularization