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Thus, to effectively treat MASH, a drug must address three key conditions: fat accumulation, inflammation, and fibrosis

Patients complained of erythematous scaly plaques on the trunk, extremities, face, and scalp

Peer review Peer review information Nature Chemistry thanks Daniel Reker and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Similarly, undiagnosed or poorly controlled psychiatric conditionsespecially binge eating disorder or depressioncan impair treatment outcomes

GLP-1s are most effective when combined with healthy lifestyle habits, such as eating nutritiously and getting regular exercise

Others are located in the dorsal raphe nucleus, which produces nearly all of the serotonin used by the forebrainthe same neurotransmitter system targeted by selective serotonin reuptake inhibitors