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Given that obesity is a major modifiable risk factor for OSAS, and that the pathogenesis of OSAS involves metabolic dysregulation, systemic inflammation, and abnormal adipose tissue distribution, tirzepatide may offer multidimensional therapeutic benefits in this context (26)

[11] Eli Lilly and Company, 'The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)', ClinicalTrials.gov identifier NCT06383390

GLP-1 receptors throughout the digestive tract explain why these complications happen

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In the phase II program, tirzepatide was also shown to improve biomarkers for cardiovascular risk and to improve NASH (6365)

doi: 10.1056/NEJMOA1607141/SUPPL_FILE/NEJMOA1607141_DISCLOSURES.PDF 15 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al