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Description
Denatured tirzepatide is biologically inactive

Differences in patient demographics and study design between the trials (OASIS-4 versus ATTAIN-1) could have contributed to the difference in reported weight loss

Where MEDVi lost points was the fine print

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Several mechanisms contribute
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GIPR co-agonism adds: adipose lipolysis, thermogenesis, and hypothalamic GLP-1R sensitisation
