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As euglycaemia is not a requirement for all cAMP-regulated signalling, it is unlikely that increases in cAMP due to increases in ATP concentration play a role in the glucose dependence of GLP-1R-mediated insulin secretion

The activation of the neurons of the central nervous system by GLP-1 and the interferences of this molecule in the pathological pathways of Parkinsons disease are shown in Figure 5

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